Enterococci: Biologic and Epidemiologic Characteristics and In Vitro Susceptibility

doi:10.1001/archinte.1982.00340240028006

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Vol. 142 No. 11, 25 October 1982

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Enterococci

Biologic and Epidemiologic Characteristics and In Vitro Susceptibility

Donald Kaye, MD

Arch Intern Med. 1982;142(11):2006-2009.

Abstract

• Enterococci cause urinary tract infection (usually asymptomatic),5% to 15% of cases of endocarditis, and rare cases of meningitis.Their role in polymicrobial infection in the abdomen and pelvisis difficult to assess. Ninety percent of enterococci are inhibitedby 4 mg/L of penicillin G, by 2 mg/L of ampicillin, and by 6mg/L of vancomycin. The penicillinase-resistant penicillins,cephalosporins, carbenicillin, and ticarcillin are at leastfourfold less active against enterococci than penicillin G,whereas piperacillin has activity equivalent to penicillin G.The addition of an aminoglycoside to penicillin, ampicillin,vancomycin or piperacillin—which are not bactericidalagainst most strains of enterococci—results in more rapidand complete bactericidal activity (ie, synergistic activity).

(Arch Intern Med 1982;142:2006-2009)

Author Affiliations

From the Department of Medicine, The Medical College of Pennsylvania, Philadelphia.

Footnotes

Reprint requests to The Medical College of Pennsylvania, 3300Henry Ave, Philadelphia, PA 19129 (Dr Kaye).

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