 |
|
Reversible Renal Insufficiency in Multiple Myeloma
Scott P. Bernstein, MD;
H. David Humes, MD
Arch Intern Med. 1982;142(12):2083-2086.
Abstract
• Forty-five patients met the criteria for the diagnosis of multiple myeloma in a retrospective chart review from 1975 to 1980. Renal insufficiency with peak serum creatinine concentration greater than 1.5 mg/dL involved 69% of all patients. Renal insufficiency was reversible in 55% of the cases. Treatment of hypercalcemia and/or chemotherapy for multiple myeloma was associated with reversibility in 88% of cases. Once renal insufficiency occurred in patients with multiple myeloma, those with reversible renal failure had a duration of survival fourfold longer (11.4 v 2.8 months) than those with Irreversible renal insufficiency. In conclusion, reversible renal insufficiency from hypercalcemia or the myeloma process itself develops in a majority of patients with multiple myeloma. If therapy reverses the renal dysfunction, a greater life expectancy occurs. Patients with multiple myeloma and renal insufficiency should, therefore, be examined for reversible causes of renal dysfunction, since if found and treated, a substantial improvement in prognosis is achieved.
(Arch Intern Med 1982;142:2083-2086)
Author Affiliations
From the Departments of Internal Medicine, University of Michigan and Veterans Administration Medical Center, Ann Arbor.
Footnotes
Accepted for publication June 30, 1982.
Reprint requests to Nephrology Section, VA Medical Center, 2215 Fuller Rd, Ann Arbor, MI 48105 (Dr Humes).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Timing of acute renal failure in multiple myeloma: two distinct outcomes?
Liborio et al.
Nephrol Dial Transplant 2004;19:3207-3208.
FULL TEXT
Renal Failure in Multiple Myeloma: Presenting Features and Predictors of Outcome in 94 Patients From a Single Institution
Blade et al.
Arch Intern Med 1998;158:1889-1893.
ABSTRACT
| FULL TEXT
Treatment of Renal Failure Associated With Multiple Myeloma: Plasmapheresis, Hemodialysis, and Chemotherapy
Johnson et al.
Arch Intern Med 1990;150:863-869.
ABSTRACT
|
