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C. Harold Mielke, Jr, MD; Charles E. Dobbs, MD; Charles F. Winkler, MD; Lung T. Yam, MD

Arch Intern Med. 1982;142(4):700-702.

Abstract
Therapeutic leukapheresis was performed on three patients, and plasmapheresis on two patients with far-advanced hairy cell leukemia. Two of the three patients who were treated with leukapheresis had many hairy cells in their peripheral blood, while the other had relatively few. In each patient, dramatic clinical and hematologic improvements were observed that have sustained for more than 23, 10, and 26 months, respectively. Plasmapheresis of similar intensity failed to show any appreciable therapeutic effects on two other patients with similar clinical and hematologic findings. We believe that the favorable therapeutic effects of leukapheresis are due to the removal of factors capable of inhibiting normal hematopoiesis. This factor(s) is present in the cells that were removed by leukapheresis. The exact nature of this factor(s) or the cells that produce this factor(s) remains to be identified.

(Arch Intern Med 1982;142:700-702)

Author Affiliations
From the Departments of Pathology and Medicine, Institutes of Medical Sciences, Pacific Medical Center, and the Department of Medicine, University of California School of Medicine, San Francisco (Dr Mielke); the Veterans Administration Medical Center and the Department of Medicine, University of Louisville School of Medicine (Dr Yam); and the Oncology Unit, Highland Baptist Hospital (Drs Dobbs and Winkler), Louisville.

Footnotes
Accepted for publication Oct 1, 1981.

Reprint requests to Institutes of Medical Sciences, Pacific Medical Center, PO Box 7999, San Francisco, CA 94120 (Dr Mielke).

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