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Combined Vitamin D Parathyroid Defect in Thalassemia Major
John F. Aloia, MD;
John A. Ostuni, MD;
James K. Yeh, PhD;
Edward C. Zaino, MD
Arch Intern Med. 1982;142(4):831-832.
Abstract
A 17-year-old girl with thalassemia major experienced tetany. The serum calcium level was 5.5 mg/dL, and the phosphorus level was 6.3 mg/dL. Serum levels of parathyroid hormone (PTH) and 25-hydroxyvitamin D (25-OHD) were subnormal at 125 pg/mL and 8.1 ng/mL, respectively. As a result of these findings, serum 25-OHD and PTH levels were measured in an additional 12 patients with thalassemia major. Low levels of both 25-OHD and PTH were found frequently. An increase in serum 25-OHD levels was noted in each of four patients who were examined after iron chelation therapy.
(Arch Intern Med 1982;142:831-832)
Author Affiliations
From the Department of Medicine, Nassau Hospital, Mineola, NY (Drs Aloia and Yeh); Mercy Hospital, Rockville Center, NY (Dr Zaino); and the Health Sciences Center State University of New York at Stony Brook (Drs Aloia, Yeh, and Ostuni).
Footnotes
Accepted for publication Oct 26, 1981.
Reprint requests to Department of Medicine, Nassau Hospital, 259 First St, Mineola, NY 11501 (Dr Aloia).
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