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State of the Art

Arnold S. Bayer, MD

Arch Intern Med. 1982;142(6):1169-1177.

Abstract
• The major clinical difficulties in bacteremic Staphylococcus aureus infections involve the following: (1) differentiation of infective endocarditis (IE) from non-IE staphylococcemias and (2) questions concerning optimum chemotherapy of deep-seated staphylococcemic infections. In this article, an algorithmic approach to the differentiation of S aureus IE from non-IE staphylococcemias will be developed, particularly in regard to specific clinical, echocardiographic, radioisotopic, and serological "markers" for recognizing patients as at "high risk" for underlying S aureus IE. Also, data will be presented relating to the controversies of monotherapy v combination chemotherapy in S aureus IE as well as in bacteremic S aureus infections caused by antibiotic-tolerant S aureus strains.

(Arch Intern Med 1982;142:1169-1177)

Author Affiliations
From the Division of Infectious Disease, Harbor-UCLA Medical Center, Torrance, Calif.

Footnotes
Accepted for publication Jan 11, 1982.

Reprinted with permission from the Bulletin of the American College of Chest Physicians (1980;3:8-19).

Reprint requests to Division of Infectious Diseases, Harbor-UCLA Medical Center, 1000 Carson St, Torrance, CA 90509 (Dr Bayer).

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