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James M. Falko, MD; Thomas M. O'Dorisio, MD; Samuel Cataland, MD

Arch Intern Med. 1982;142(7):1370-1371.

Abstract
• Measurement of glycosylated hemoglobin (HbA₁) is frequently helpful to clinicians in treating patients with diabetes, since a number of studies show that this reflects a reliable index of diabetic control over time. There are several methods of measuring HbA₁. The chromatographic method is the most frequently used and is the standard method for large demand. We recently encountered a patient with diabetes mellitus who had substantial lactescent plasma secondary to hypertriglyceridemia that falsely raised the HbA₁ level. We examined the patient in detail and determined that triglyceride concentrations greater than 1,750 mg/dL would falsely raise the HbA₁ levels. In vitro studies performed by adding lipemic plasma to a control sample confirmed this. Thus, spurious elevations in HbA₁ can occur in patients with lactescent plasma. This would further complicate the already existing interrelationship between glucose intolerance and hypertriglyceridemia.

(Arch Intern Med 1982;142:1370-1371)

Author Affiliations
From the Division of Endocrinology, Ohio State University Hospitals, Columbus.

Footnotes
Accepted for publication March 30, 1982.

Reprint requests to Ohio State University Hospitals, 410 W Tenth Ave, Room N-1111, Columbus, OH 43210 (Dr Falko).

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