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Lipid Metabolism in Non-Insulin-Dependent Diabetes MellitusEffect of Glipizide Therapy
Michael S. Greenfield, MD;
Leonard Doberne, MD;
Mark Rosenthal, MD;
Hendrik J. Vreman, PhD;
Gerald M. Reaven, MD
Arch Intern Med. 1982;142(8):1498-1500.
Abstract
• Plasma lipid concentration and lipoprotein composition were studied before and after several months of glipizide treatment in 23 patients with non-insulin-dependent diabetes mellitus. The mean (±SEM) plasma glucose level fell 87 mg/dL, and the fall in plasma glucose concentration was correlated with a reduction in plasma triglyceride, very low-density lipoprotein triglyceride, cholesterol, and low-density lipoprotein cholesterol levels. Furthermore, there was a statistically significant increase in the plasma high-density lipoprotein cholesterol to total cholesterol ratio. Thus, improved diabetic control in patients treated with glipizide with non-insulin-dependent diabetes mellitus leads to changes in lipoprotein metabolism thought to be beneficial in terms of known cardiovascular risk factors.
(Arch Intern Med 1982;142:1498-1500)
Author Affiliations
From the Department of Medicine, Stanford University School of Medicine; and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Palo Alto, Calif.
Footnotes
Accepted for publication April 6, 1982.
Reprint requests to Geriatric Research, Education and Clinical Center, Room 182B, 3801 Miranda Ave, Palo Alto, CA 94304 (Dr Reaven).
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