 |
|
Classic Gout in Hageman Factor (Factor XII) Deficiency
David Green, MD, PhD;
Christiane L. Arsever, MD;
Kenneth A. Grumet, MD;
Oscar D. Ratnoff, MD
Arch Intern Med. 1982;142(8):1556-1557.
Abstract
A 62-year-old man with a typical history of gout was admitted to the hospital with left-sided hemiplegia. His serum uric acid level was 10.3 mg/dL, his partial thromboplastin time was 198 s, and his Hageman factor (factor XII) coagulant activity and antigen were less than 1% of normal. Aspiration of synovial fluid from his inflamed knee disclosed urate crystals and abundant leukocytes but an absence of Hageman factor antigen. The presence of acute gouty arthritis in a patient with Hageman trait challenges the role of Hageman factor in the pathogenesis of gouty arthropathy.
(Arch Intern Med 1982;142:1556-1557)
Author Affiliations
From the Atherosclerosis Program, Rehabilitation Institute of Chicago (Dr Green); the Departments of Medicine, Veterans Administration Lakeside Hospital and Northwestern University Medical School, Chicago (Drs Green, Arsever, and Grumet); and Case Western Reserve University School of Medicine, Cleveland (Dr Ratnoff).
Footnotes
Accepted for publication April 29, 1982.
Reprint requests to Atherosclerosis Program, Northwestern University, Rehabilitation Institute of Chicago, 345 E Superior St, Room 1407, Chicago, IL 60611 (Dr Green).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Factor XII Deficiency in a Man With Gout and Angioimmunoblastic Lymphadenopathy
Londino and Luparello
Arch Intern Med 1984;144:1497-1498.
ABSTRACT
|
