This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Patricia A. Johnson, MD, PhD; Arthur H. Rossof, MD

Arch Intern Med. 1983;143(1):111-114.

Abstract
• The human tumor stem cell assay is a technique that allows in vitro sensitivity testing of antineoplastic agents against cells from tumor specimens removed from patients. This assay predicts clinical response to drugs and permits Individualization of chemotherapy. It is more accurate in predicting drug resistance than drug sensitivity. Although there are technical problems with the assay, it has been successfully applied to nearly every possible type of human solid tumor and can be performed using cells from malignant effusions as well. Screening of new agents for activity against a range of human tumor specimens may prove to be the most important application of the human tumor stem cell assay.

(Arch Intern Med 1983;143:111-114)

Author Affiliations
From the Department of Internal Medicine, Rush-Presbyterian— St Luke's Medical Center, Chicago. Dr Johnson is now with the Carle Clinic, Urbana, Ill.

Footnotes
Accepted for publication June 21, 1982.

Reprint requests to Carle Clinic, Urbana, IL 61801 (Dr Johnson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?