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Genetic Linkage With 1-Antitrypsin Deficiency

Nguyen Dinh Phung, MD; Ronald J. Harbeck, PhD; Celia Helbling-Muntges, MA

Arch Intern Med. 1983;143(3):575-577.

Abstract
• Familial hypogammaglobulinemia was found to exist in a large kindred. Phenotyping of ₁-antitrypsin in 31 persons from seven families related to the patient in the index case suggests linkage of hypogammaglobulinemia with the protease inhibitor locus for ₁-antitrypsin.

(Arch Intern Med 1983;143:575-577)

Author Affiliations
From the Departments of Medicine, University of Oklahoma College of Medicine and Oklahoma City Veterans Administration Medical Center, Oklahoma City (Dr Phung); the Department of Microbiology and Immunology, University of Colorado Medical School, Denver (Dr Harbeck); and the Clinical Immunology Laboratory, National Jewish Hospital and Research Center, Denver (Ms Helbling-Muntges).

Footnotes
Accepted for publication Sept 2, 1982.

Reprint requests to VA Medical Center, Ambulatory Care Clinic 11C, Oklahoma City, OK 73104 (Dr Phung).

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