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Report of a Case and Review of the Literature

Dickerman Hollister, Jr, MD; Margaret Clements, MD; Morton Coleman, MD; Frank Petito, MD

Arch Intern Med. 1983;143(3):590-592.

Abstract
• Eosinophilic meningitis is rare in Hodgkin's disease. Five previous cases have been reported. We describe an additional patient whose CSF showed an eosinophilic pleocytosis with Reed-Sternberg cells while in complete systemic remission from Hodgkin's disease. The patient responded to intrathecal administration of methotrexate given by Ommaya reservoir. Six months later, systemic relapse occurred, but the CSF remained normal. Eosinophilic meningitis is a treatable complication of Hodgkin's disease, and prolonged response is possible.

(Arch Intern Med 1983;143:590-592)

Author Affiliations
From the Departments of Internal Medicine (Drs Hollister and Coleman), Pathology (Dr Clements), and Neurology (Dr Petito), The New York Hospital-Cornell Medical Center.

Footnotes
Accepted for publication July 30, 1982.

Reprint requests to Hematology-Oncology Department, The New York Hospital, 525 E 68th St, New York, NY 10021 (Dr Coleman).

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