This Article  • References  • Full text PDF  • Correction  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (151)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Raymond A. Smego, Jr, MD; Mark B. Moeller, MD; Harry A. Gallis, MD

Arch Intern Med. 1983;143(4):711-718.

Abstract
• The optimal therapy for infections due to Nocardia species has not been established. To assess the efficacy of trimethoprim-sulfamethoxazole (TMP-SMX), we reviewed the records of 19 patients with Nocardia infections seen at Duke University Medical Center, Durham, NC, who were treated with this drug, either alone or in combination with other antibiotics or a surgical procedure. Underlying diseases or therapy causing immunosuppression were present in all but five cases. Sites of involvement were lung (ten of 19), wound (two of 19), and brain (two of 19); five of 19 patients had disseminated disease. The mean duration of therapy was 7.2 months. Overall cure or improvement was achieved in 89% (17/19) of cases; 80% of patients with disseminated disease and 60% of those with CNS involvement recovered. This experience, and accumulated clinical evidence in the literature, indicates that TMP-SMX should be considered the therapeutic drug of choice in infections due to Nocardia species.

(Arch Intern Med 1983;143:711-718)

Author Affiliations
From the Division of Infectious Diseases, the Department of Medicine, Duke University Medical Center, Durham, NC.

Footnotes
Accepted for publication Oct 18, 1982.

Reprint requests to Box 3306, Duke University Medical Center, Durham, NC 27710 (Dr Smego).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Into the Woods
Safdar et al.
NEJM 2007;356:943-947.
FULL TEXT  

Endogenous Nocardia asteroides Endophthalmitis
Ng et al.
Arch Ophthalmol 2002;120:210-213.
FULL TEXT  

Chronic non-healing ulcers of the scalp after trauma
Postgrad. Med. J. 2000;76:439i-439.
FULL TEXT  

Biochemical-Genetic Analysis and Distribution of FAR-1, a Class A beta -Lactamase from Nocardia farcinica
Laurent et al.
Antimicrob. Agents Chemother. 1999;43:1644-1650.
ABSTRACT | FULL TEXT  

A Palmar Chancre and Multiple Proximal Erythematous Nodules
Johnson and Meier
Arch Dermatol 1996;132:967-968.
ABSTRACT  

Primary Cutaneous Nocardiosis Mimicking Sporotrichosis
Wlodaver et al.
Arch Dermatol 1988;124:659-660.
ABSTRACT  

Primary Lymphocutaneous Nocardia brasiliensis Infection
Moeller and Burton
Arch Dermatol 1986;122:1180-1182.
ABSTRACT  

Disseminated Nocardia brasiliensis Infection Following Cryptococcal Disease
Schreiner et al.
Arch Dermatol 1986;122:1186-1190.
ABSTRACT