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Jan I. M. Drayer, MD; Michael A. Weber, MD; Janice L. DeYoung; Deborah D. Brewer

Arch Intern Med. 1983;143(5):898-901.

Abstract
• Noninvasive BP monitoring was performed in hypertensive patients before and during placebo therapy and before and during therapy with the long-acting peripheral -adrenergic receptor antagonist, terazosin hydrochloride. Placebo therapy did not result in significant changes in casual BP or in averages of whole-day, daytime, or nighttime BPs. Short-term therapy with terazosin did not induce significant changes in casual supine or daytime BPs. However, whole-day BP monitoring disclosed that nighttime BPs were lower during short-term therapy. Moreover, the circadian pattern of BP was shifted downward during terazosin therapy. Long-term therapy with terazosin resulted in significant changes in BP. All BP values were lowered significantly. The differences in the circadian BP pattern between placebo and long-term terazosin therapy show that in these patients BP was lowered throughout the 24 hours of the day. The results of the study emphasize the usefulness of 24-hour BP monitoring in the evaluation of the effectiveness of long-acting antihypertensive agents.

(Arch Intern Med 1983;143:898-901)

Author Affiliations
From the Section of Clinical Pharmacology and Hypertension, Veterans Administration Medical Center, Long Beach, Calif; and the University of California, Irvine.

Footnotes
Accepted for publication Jan 24, 1983.

Reprint requests to the Hypertension Center W130, VA Medical Center, 5901 E Seventh St, Long Beach, CA 90822 (Dr Drayer).

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