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Successful Ketoconazole Treatment of Protothecosis With Ketoconazole-Associated Hepatotoxicity
P. Samuel Pegram, Jr, MD;
Fred T. Kerns, MD;
Benedict L. Wasilauskas, PhD;
Kenneth D. Hampton;
Modesto Scharyj, MD;
J. Gillum Burke, MD
Arch Intern Med. 1983;143(9):1802-1805.
Abstract
• A 46-year-old woman had a chronic, unresponsive wrist infection that was proved to be due to the algaelike organism Prototheca wickerhamii. Treatment with ketoconazole resulted in prompt improvement and ultimate healing. Therapy was complicated by hepatitis that was ketoconazole-related. Ketoconazole may be effective and easily administered therapy for this generally unresponsive infection.
(Arch Intern Med 1983;143:1802-1805)
Author Affiliations
From the Departments of Medicine (Drs Pegram and Kerns) and Pathology (Drs Wasilauskas and Scharyj and Mr Hampton), Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC; and the Surry Orthopedic Associates, Mount Airy, NC (Dr Burke).
Footnotes
Accepted for publication Nov 16, 1982.
Reprint requests to the Department of Medicine, 300 S Hawthorne Rd, Winston-Salem, NC 27103 (Dr Pegram).
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