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Spontaneous Hypoglycemic Seizures in PregnancyA Manifestation of Panhypopituitarism
Robyn B. Notterman;
Lois Jovanovic, MD;
Ralph Peterson, MD;
Gail Solomon, MD;
Maurice Druzin, MD;
Charles M. Peterson, MD
Arch Intern Med. 1984;144(1):189-191.
Abstract
• A 32-year-old woman had seizures and coma due to severe hypoglycemia (26 mg/dL) in the 32nd week of an otherwise uncomplicated pregnancy. She responded dramatically to the administration of cortisol. Initial endocrine evaluation disclosed prolactin (PRL), corticotropin, and thyrotropin (TSH) deficiencies. The patient recovered completely with cortisol and thyroid hormone therapy and was delivered of a healthy male child at term. Endocrine reevaluations one week and six months postpartum disclosed luteinizing hormone, follicle-stimulating hormone, growth hormone, PRL, corticotropin, and probable TSH deficiencies. The cause of this panhypopituitarism has not been determined. This case suggests that the appropriate initial treatment for spontaneous symptomatic hypoglycemia in pregnancy, while awaiting further endocrine evaluation, is the administration of cortisol.
(Arch Intern Med 1984;144:189-191)
Author Affiliations
From the Departments of Medicine (Ms Notterman and Drs Jovanovic and R. Peterson), Obstetrics and Gynecology (Dr Druzin), and Pediatrics (Dr Solomon), Cornell University Medical College, and The Rockefeller University (Dr C. M. Peterson), New York.
Footnotes
Accepted for publication April 11, 1983.
Reprint requests to Cornell University Medical College, 515 E 71st St, New York, NY 10021 (Dr Jovanovic).
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