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Paul D. Mitnick, MD; William J. Klein, Jr, MD

Arch Intern Med. 1984;144(1):63-64.

Abstract
• Two cases of nephrotoxicity associated with piroxicam therapy are reported. In the first case, severe reversible azotemia with hyperkalemia resolved after discontinuation of the medication. In the second case, biopsy-proved acute interstitial nephritis with immune complex glomerulonephritis and hepatitis improved after steroid therapy. The mechanism for such toxicity may be altered hemodynamics, cellular immunity, or humoral immunity related to prostaglandin inhibition.

(Arch Intern Med 1984;144:63-64)

Author Affiliations
From the Sections of Nephrology, Reading Hospital and Medical Center, West Reading, and St Joseph Hospital, Reading, Penn.

Footnotes
Accepted for publication July 25, 1983.

Reprint requests to 301 S Seventh Ave, West Reading, PA 19611 (Dr Mitnick).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Severe Hyperkalemia During Piroxicam Therapy
Miller et al.
Arch Intern Med 1984;144:2414-2415.
ABSTRACT