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Arrhythmias in Mitral Valve ProlapseEffect of Selection Bias
Harvey M. Kramer, MD;
Paul Kligfield, MD;
Richard B. Devereux, MD;
Daniel D. Savage, MD;
Randi Kramer-Fox, MS
Arch Intern Med. 1984;144(12):2360-2364.
Abstract
• To assess the contribution of bias in subject selection to the prevalence of arrhythmias in cases of mitral valve prolapse (MVP), we compared ambulatory arrhythmias in 63 patients with MVP and 28 symptom-matched control subjects. All subjects were in sinus rhythm. Mean 24-hour heart rate of the prolapse population was lower than that of the control group (76 vv 82 beats per minute). Mean atrial premature complex (APC) density per 1,000 beats (0.9 v 0.7 for patients with MVP and control subjects, respectively) and mean ventricular premature complex (VPC) density per 1,000 total beats (1.2 v 1.5) did not differ between groups. Small differences between groups in APC and VPC complexity did not reach statistical significance. Our findings suggest that, compared with similarly symptomatic controls, patients with MVP do not have as high an excess prevalence of arrhythmias as previously believed.
(Arch Intern Med 1984;144:2360-2364)
Author Affiliations
From the Division of Cardiology, The New York Hospital—Cornell Medical Center, New York (Drs Kramer, Kligfield, and Devereux, and Ms Kramer-Fox) and the Framingham (Mass) Heart Study (Dr Savage).
Footnotes
Accepted for publication April 16, 1984.
Reprint requests to the Division of Cardiology, The New York Hospital—Cornell Medical Center, 525 E 68th St, New York, NY 10021 (Dr Kligfield).
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