Clinical and Chemical Assessment of Thyroid Function During Therapy With Amiodarone

doi:10.1001/archinte.1984.00350150071023

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Vol. 144 No. 3, March 1984

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Clinical and Chemical Assessment of Thyroid Function During Therapy With Amiodarone

Janet A. Amico, MD; Vanessa Richardson, MD; Barry Alpert, MD; Irwin Klein, MD

Arch Intern Med. 1984;144(3):487-490.

Abstract

• Clinical and chemical variables of thyroid function werestudied in 26 patients with symptomatic ventricular tachyarrhythmiasbefore and during long-term oral treatment with amiodarone.The mean (±SEM) pretreatment thyroxine (T₄) level inthe 26 patients was 7.32±0.33 µg/dL, and increasednotably to 10.15±0.47 µg/dL by 30 to 120 days aftertreatment. The free thyroxine index (FT₄I) was also notablyelevated. Clinical hyperthyroidism or goiter did not develop,but clinical hypothyroidism occurred in four patients duringand in one patient after discontinuation of amiodarone treatment.Notable titers of antithyroid antibodies were found in the serumof two of the five and a family history of thyroid disease waspresent in three of the five hypothyroid patients. An elevationof both the T₄ level and the FT₄I above the normal range isan expected finding in patients receiving amiodarone and doesnot by itself indicate hyperthyroidism. Patients with positiveantithyroid antibodies or a family history of thyroid diseaseprior to treatment with amiodarone may be at an increased riskof hypothyroidism developing when treated with this drug.

(Arch Intern Med 1984;144:487-490)

Author Affiliations

From the Department of Medicine, University of Pittsburgh School of Medicine (Drs Amico, Alpert, and Richardson), and the Pittsburgh Veterans Administration Hospital (Dr Klein).

Footnotes

Accepted for publication Sept 27, 1983.

Reprint requests to 930 Scaife Hall, University of PittsburghSchool of Medicine, Pittsburgh, PA 15261 (Dr Amico).

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