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Acute Oligoarthritis Associated With Clostridium difficile Pseudomembranous Colitis
Richard P. Lofgren, MD;
Lauri M. Tadlock, MD;
Ronald D. Soltis, MD
Arch Intern Med. 1984;144(3):617-619.
Abstract
The abrupt onset of a sterile inflammatory oligoarthritis developed in a patient with active Clostridium difficile pseudomembranous colitis. The arthritis affected a hip and a knee. Leukocyte counts of synovial fluid obtained from the patient's left hip and knee were elevated. He was haplotyped as HLA-B27 antigen-positive. The colitis and arthritis promptly abated after treatment with oral vancomycin hydrochloride. Three other cases of arthritis associated with antibiotic-induced colitis were reviewed. It seems as if treatment of the colitis leads to resolution of the arthritis.
(Arch Intern Med 1984;144:617-619)
Author Affiliations
From the Department of Medicine, Michigan State University, East Lansing (Dr Lofgren); the Department of Medicine, University of Minnesota, Minneapolis (Drs Tadlock and Soltis); and the Minneapolis Veteran's Administration Hospital (Dr Tadlock).
Footnotes
Accepted for publication Aug 4, 1983.
Reprint requests to the Department of Medicine, B220 Life Sciences Bldg, Michigan State University, East Lansing, MI 48824 (Dr Lofgren).
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