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Liver Damage in Disorders of Iron OverloadA Hypothesis
Munsey S. Wheby, MD
Arch Intern Med. 1984;144(3):621-622.
Abstract
• The pathogenesis of liver damage in patients with iron loading disorders is not explained. Evidence concerning the following hypothesis is reviewed: Iron, absorbed from the intestinal tract when transferrin saturation is complete or almost so, remains unbound and is lost into the liver on first passage through the portal circulation. By still-to-be-determined molecular events, unbound iron is toxic to liver cells and produces progressive damage when this process occurs repeatedly.
(Arch Intern Med 1984;144:621-622)
Author Affiliations
From the Division of Hematology/Oncology, the Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville.
Footnotes
Accepted for publication April 25, 1983.
Reprint requests to Department of Medicine, Box 502, University of Virginia School of Medicine, Charlottesville, VA 22908 (Dr Wheby).
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