This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

John H. Rodman, PharmD; Roger W. Jelliffe, MD; Earl Kolb, MD; Daniel B. Tuey, PhD; Maria F. de Guzman, MD; Park W. Wagers, MD; L. Julian Haywood, MD

Arch Intern Med. 1984;144(4):703-709.

Abstract
• A randomized prospective study compared achievement and maintenance of therapeutic plasma concentrations in patients receiving computer-assisted (CA) initial lidocaine hydrochloride therapy, designed pharmacokinetically to achieve and maintain a chosen plasma concentration, v conventional lidocaine therapy (CT). A separate audit of outcome was also conducted. The CA regimens provided more effective concentrations in the first hour than did CT, 2.65 v 1.5 µg/mL average. In the audit, ventricular fibrillation occurred in two of 78 CA v eight of 78 CT patients. Dosage adjustments were required in two CA patients v 33 CT patients. The CA therapy improved therapeutic precision, reduced dosage adjustments, and may have improved safety during initial lidocaine therapy before fitting to plasma concentration data for subsequent feedback. An improved clinical computer program now also fits to plasma concentration data. It is accessed and used routinely by hospitals over an international timesharing network.

(Arch Intern Med 1984;144:703-709)

Author Affiliations
From the Laboratory of Applied Pharmacokinetics and the Sections of Clinical Pharmacy (Dr Rodman), Clinical Pharmacology (Drs Jelliffe and Tuey), Cardiology (Drs de Guzman and Haywood), and Intensive Care (Dr Wagers), the University of Southern California Schools of Medicine and Pharmacy, and the Community Hospital of the Monterey Peninsula, Carmel, Calif (Dr Kolb). Dr Tuey is now with the Pharmacontrol Corp, Englewood Cliffs, NJ; Dr Rodman is now with the Department of Pharmaceutical Services, University of Minnesota Hospitals, Minneapolis.

Footnotes
Accepted for publication Aug 24, 1983.

Reprint requests to Department of Pharmaceutical Services, University of Minnesota Hospitals, Box 611, Mayo Memorial Building, 420 Delaware St SE, Minneapolis, MN 55455 (Dr Rodman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

"Smart Forms" in an Electronic Medical Record: Documentation-based Clinical Decision Support to Improve Disease Management
Schnipper et al.
J. Am. Med. Inform. Assoc. 2008;15:513-523.
ABSTRACT | FULL TEXT  

Effects of Computerized Clinical Decision Support Systems on Practitioner Performance and Patient Outcomes: A Systematic Review
Garg et al.
JAMA 2005;293:1223-1238.
ABSTRACT | FULL TEXT  

Computer support for determining drug dose: systematic review and meta-analysis
Walton et al.
BMJ 1999;318:984-990.
ABSTRACT | FULL TEXT  

Effects of Computer-Based Clinical Decision Support Systems on Physician Performance and Patient Outcomes: A Systematic Review
Hunt et al.
JAMA 1998;280:1339-1346.
ABSTRACT | FULL TEXT  

Effect of Phenobarbital on the Pharmacokinetics of Lidocaine, Monoethylglycinexylidide and 3-Hydroxylidocaine in the Rat: Correlation with P450 Isoform Levels
Nakamoto et al.
Drug Metab. Dispos. 1997;25:296-300.
ABSTRACT | FULL TEXT  

The Clinical Value of Computerized Information Services: A Review of 98 Randomized Clinical Trials
Balas et al.
Arch Fam Med 1996;5:271-278.
ABSTRACT  

Computer-Aided Quality Assurance: A Critical Appraisal
Haynes and Walker
Arch Intern Med 1987;147:1297-1301.
ABSTRACT  

Lidocaine Poisoning: Treatment and Prevention
Nicholson
JAMA 1985;254:2889-2890.
ABSTRACT  

Simple Method for Maintaining Serum Lidocaine Levels in the Therapeutic Range
Wong and Hurwitz
Arch Intern Med 1985;145:1588-1591.
ABSTRACT