This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (33)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Immune Complex-Mediated Vessel Damage and Increased Neutrophil Migration

Joseph L. Jorizzo, MD; Frank C. Schmalstieg, MD, PhD; Scott M. Dinehart; Jerry C. Daniels, MD, PhD; Tito Cavallo, MD; Prapand Apisarnthanarax, MD; Helen B. Rudloff; Emilio B. Gonzalez, MD

Arch Intern Med. 1984;144(4):738-740.

Abstract
• In a recent report we described a syndrome, identical to bowel-bypass syndrome, that occurred in four patients who had not had bypass surgery. Herein, circulating immune complexes (CICs) and neutrophil migration are evaluated in three of those four patients to test the hypothesis that the cutaneous lesions might have resulted from interaction between immune complex—mediated vessel damage and increased neutrophil migration. In vitro assays indicated that CICs were present in one of two patients and "histamine trap" test evidence for CICs was present in both patients tested. Although serum from the three patients appeared to increase neutrophil movement, statistically significant increases were not observed when data were pooled in this small study group. Preliminary results suggest that immune complex—mediated vessel damage, followed by extensive accumulation of neutrophils, may cause the pustular vasculitis in the bowel-associated dermatosisarthritis syndrome.

(Arch Intern Med 1984;144:738-740)

Author Affiliations
From the Department of Dermatology (Drs Jorizzo and Apisarnthanarax and Mr Dinehart), the Division of Immunology and Allergy, Department of Pediatrics (Dr Schmalstieg and Ms Rudloff), the Division of Immunology and Rheumatology, Department of Internal Medicine (Drs Daniels and Gonzalez), and the Division of Renal Immunopathology, Department of Pathology (Dr Cavallo), University of Texas Branch at Galveston.

Footnotes
Accepted for publication Sept 26, 1983.

Reprint requests to Department of Dermatology, the University of Texas Medical Branch at Galveston, Galveston, TX 77550 (Dr Jorizzo).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Primary Systemic Pustular Vasculitis With Severe Intestinal Involvement
Abe et al.
Arch Dermatol 1992;128:1408-1410.
ABSTRACT  

Purpuric Rashes in Cystic Fibrosis
Schidlow et al.
Arch Pediatr Adolesc Med 1989;143:1030-1032.
ABSTRACT  

Thalidomide Effects in Behcet's Syndrome and Pustular Vasculitis
Jorizzo et al.
Arch Intern Med 1986;146:878-881.
ABSTRACT  

Behcet's Syndrome Complicated by Cutaneous Leukocytoclastic Vasculitis: Response to Prednisone and Chlorambucil
Plotkin et al.
Arch Intern Med 1985;145:1913-1915.
ABSTRACT