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D. Ward Slingerland, MD; John A. Cardarelli, MS; Belton A. Burrows, MD; Aaron Miller, MD

Arch Intern Med. 1984;144(6):1167-1168.

Abstract
• Elevated levels of serum gastrin as a consequence of gastric achlorhydria are characteristic of clinical pernicious anemia. In a largely male hospitalized population with an average age of 64 years, 7.7% had low levels of serum B₁₂ (<170 pg/mL); only 2.5% of these had frank pernicious anemia. In an attempt to separate a subgroup with low levels of serum B¹² in whom pernicious anemia may later develop, their serum gastrin levels were determined. Twenty-two percent had high values and, of these, 70% had low B₁₂ absorptions. In patients with low serum B₁₂ levels, serum gastrin assays may be useful in determining those in whom clinical pernicious anemia seems likely to develop.

(Arch Intern Med 1984;144:1167-1168)

Author Affiliations
From the Nuclear Medicine (Drs Slingerland and Burrows and Mr Cardarelli) and Medical Services (Dr Miller), Veterans Administration Medical Center, and Boston University School of Medicine (Drs Slingerland, Burrows, and Miller).

Footnotes
Accepted for publication Nov 28, 1983.

Reprint requests to Nuclear Medicine Service, VA Medical Center, 150 S Huntington Ave, Boston, MA 02130 (Dr Slingerland).

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