 |
|
Effect of Clonidine Therapy on Renal Hemodynamics in Renal Transplant Hypertension
Sandra Green, BSN;
Edward T. Zawada, Jr, MD;
Wael Muakkassa, MD;
Michael Johnson;
Thomas Mackenzie, MD;
Mark McClanahan;
Ann Graybill, MD;
Mitchell, MD
Arch Intern Med. 1984;144(6):1205-1208.
Abstract
• Antihypertensive medications have a variable effect on renal hemodynamics and may contribute to renal insufficiency in some patients. Since clonidine has actually been found to Improve renal hemodynamics in patients with essential hypertension, we studied the effects of clonidine therapy in patients with renal transplant hypertension. Baseline measurements of BP and renal hemodynamics were made in six patients after two weeks of therapy with furosemide. Clonidine was then added and titrated until BP was controlled. Repeated measurements of renal hemodynamics were made four and 16 weeks after clonidine therapy was begun. Glomerular filtration and effective renal plasma flow as assessed by inulin and aminohippurate sodium clearances were preserved during prolonged clonidine therapy.
(Arch Intern Med 1984;144:1205-1208)
Author Affiliations
From the Departments of Medicine (Drs Zawada and Mackenzie, Ms Green, and Messrs Johnson and McClanahan) and Surgery (Drs Muakkassa, Graybill, and Goldman), McGuire Veterans Administration Medical Center and Medical College of Virginia, Richmond.
Footnotes
Accepted for publication Jan 3, 1984.
Reprint requests to University of South Dakota School of Medicine, 2501 W 22nd St, Sioux Falls, SD 57101 (Dr Zawada).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Use of Centrally Acting Sympatholytic Agents in the Management of Hypertension
Oster and Epstein
Arch Intern Med 1991;151:1638-1644.
ABSTRACT
|
