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Joseph Layon, MD; Ahamed Idris, MD; Michael Warzynski, PhD; Renslow Sherer, MD; Daniel Brauner, MD; Olivia Patch, MD; Dorris McCulley, MD; Peter Orris, MD, MPH

Arch Intern Med. 1984;144(7):1376-1380.

Abstract
• Baseline immunologic abnormalities were identified in 16 hospitalized intravenous drug abusers (IDAs) without acquired immune deficiency syndrome (AIDS). Twelve (75%) of 16 had inverted helper-suppressor ratios. In seven patients (44%), the abnormal ratio resulted from an increase in the absolute number of suppressor cells with a normal number of helper T lymphocytes. In five patients (31%), the reduced ratio resulted primarily from decreased helper cells, immunophenotypic findings similar to those seen in patients with AIDS. These findings are similar to what has been noted in other groups at risk for AIDS. Longitudinal follow-up as well as studies of "healthy" IDAs are required to understand the prognostic implications of these data.

(Arch Intern Med 1984;144:1376-1380)

Author Affiliations
From the Department of Medicine (Drs Layon, Idris, Sherer, Brauner, Patch, McCulley, and Orris) and the Division of Immunology of the Department of Laboratories (Dr Warzynski), Cook County Hospital, Chicago. Dr Layon is now with the University of Florida College of Medicine, Gainesville.

Footnotes
Accepted for publication Dec 14, 1983.

Reprint requests to Department of Anesthesiology, Division of Critical Care Medicine, Box J-254, J. Hillis Miller Health Center, Gainesville, FL 32610 (Dr Layon).

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