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Overwhelming Sepsis in the Adult Variant of Wiskott-Aldrich Syndrome
Arthur L. Horwich, MD;
Margretta R. Seashore, MD;
John M. Dwyer, PhD
Arch Intern Med. 1984;144(7):1498-1500.
Abstract
• Two brothers with a variant form of Wiskott-Aldrich syndrome suffered episodes of severe bacterial infection commencing in their fourth decade of life. One man died of overwhelming pneumococcal infection. This study emphasizes (1) the importance of recognizing the variant form of Wiskott-Aldrich syndrome in male adults with thrombocytopenia and (2) the treatment of these patients with prophylactic antibiotics.
(Arch Intern Med 1984;144:1498-1500)
Author Affiliations
From the Departments of Human Genetics (Drs Horwich and Seashore), Medicine (Dr Dwyer), and Pediatrics (Drs Horwich, Seashore, and Dwyer), Yale University School of Medicine, New Haven, Conn.
Footnotes
Accepted for publication July 26, 1983.
Reprint requests to the Department of Human Genetics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510 (Dr Horwich).
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