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Contrasting Short- and Long-term Effects of Weight Loss on Lipoprotein Levels
Michael J. Follick, PhD;
David B. Abrams, PhD;
Timothy W. Smith, PhD;
L. Omar Henderson, PhD;
Peter N. Herbert, MD
Arch Intern Med. 1984;144(8):1571-1574.
Abstract
• The short- and long-term effects of weight loss on high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels were examined In 42 women who completed a 14-session behavioral weight-loss program. Lipid values were determined from samples taken before treatment, after treatment, and at six-month follow-up. There were significant changes in plasma lipid levels, but the short- and long-term effects differed. Both total and LDL cholesterol levels decreased during treatment and remained lower at follow-up. However, HDL cholesterol level and the HDL/LDL ratio did not change during treatment but increased significantly above pretreatment levels at follow-up. Furthermore, long-term changes In lipoprotein levels were significantly correlated with changes in the body-mass index even after correction for Initial values. These results show that weight loss can, in the long term, have a potentially beneficial impact on lipoprotein levels in women.
(Arch Intern Med 1984;144:1571-1574)
Author Affiliations
From the Division of Behavioral Medicine, Brown University Program in Medicine, The Miriam Hospital, Providence, RI.
Footnotes
Accepted for publication Feb 7, 1984.
Reprint requests to Division of Behavioral Medicine, The Miriam Hospital, 164 Summit Ave, Providence, RI 02906 (Dr Follick).
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