Antibiotics in Patients With Neutropenia

doi:10.1001/archinte.1984.00350210173029

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Vol. 144 No. 9, September 1984

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Antibiotics in Patients With Neutropenia

Gerald P. Bodey, MD

Arch Intern Med. 1984;144(9):1845-1851.

Abstract

• Successful treatment of infection In patients with neutropeniais usually possible if several principles are followed. Themost important of these is prompt administration of antibiotictherapy, even if the patient has no symptoms or signs of Infectionother than fever. Most infections are caused by gram-negativebacilli, but even "nonpathogenic" organisms can cause seriousinfections. Antibiotic combinations should be selected thatprovide broad-spectrum coverage and are active against the mostprevalent organisms in the hospital. Aminoglycosides are oftenineffective in patients with persistent neutropenia and shouldnot be used alone. A variety of effective combination regimensare available for initial therapy of presumed or proved infectionin patients with neutropenia, Including a β-lactam plusan aminoglycoside or two β-lactam antibiotics.

(Arch Intern Med 1984;144:1845-1851)

Author Affiliations

From the Section of Infectious Diseases, Department of Internal Medicine, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston.

Footnotes

Accepted for publication Feb 6, 1984.

Reprint requests to Section of Infectious Diseases, Departmentof Internal Medicine, The University of Texas System CancerCenter, M. D. Anderson Hospital and Tumor Institute, 6723 BertnerAve, Houston, TX 77030 (Dr Bodey).

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