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Sheldon G. Sheps, MD; Alexander Schirger, MD; Ralph E. Spiekerman, MD; Thomas R. Harman, MD; Peter C. O'Brien, PhD; M. Kay Kleven; Kathryn Kremer-Simpson

Arch Intern Med. 1985;145(1):54-57.

Abstract
• Pindolol, a nonselective β-adrenergic blocking drug, lowered systolic and diastolic BP equally well during once-daily and twice-daily dosage. Side effects were few. Absence of supine bradycardia distinguished this drug from other β-adrenergic blockers and likely was attributable to the agent's intrinsic sympathomimetic activity. Blood pressure variability was less during therapy. Automatic indirect BP monitoring reliably confirmed office and home BP recordings and indicated good control throughout waking and sleeping periods.

(Arch Intern Med 1985;145:54-57)

Author Affiliations
From the Divisions of Cardiovascular Diseases and Internal Medicine (Drs Sheps and Schirger and Ms Kremer-Simpson), Community Internal Medicine (Dr Spiekerman), and Family Medicine (Dr Harman), the Department of Medical Statistics and Epidemiology (Dr O'Brien), and the Renal Laboratory (Ms Kleven), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Footnotes
Accepted for publication May 3, 1984.

Reprint requests to Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Dr Sheps).

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