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Edward T. Zawada, Jr, MD; Michael Johnson; Thomas Mackenzie, MD; Domenic A. Sica, MD; Wael Muakkassa, MD; Sandra J. Green; Mitchell Goldman, MD

Arch Intern Med. 1985;145(1):82-84.

Abstract
• Studies were undertaken to determine levels of hemoglobin A₁ in renal and heart transplant recipients. Hemoglobin A₁ was measured by separation from Hb A using an affinity-column chromatography system. Significantly elevated levels of Hb A₁ were found in all renal transplant patients; diabetic transplant recipients had the highest levels. There was no correlation between serum creatinine and Hb A₁ levels in these transplant recipients. The Hb A₁ level did correlate with the prior level of glycemia in these patients. Our findings raised the specter of the consequences of disturbed carbohydrate metabolism in these patients as not being different than that observed with other forms of end-stage renal disease management. Finally, in both diabetic and nondiabetic renal transplant recipients, measurement of Hb A₁ can serve as a useful adjunct to assess prior glycemia when such information is not available to the clinician.

(Arch Intern Med 1985;145:82-84)

Author Affiliations
From the Department of Medicine, University of South Dakota School of Medicine, and Sioux Falls Veterans Administration Medical Center, Sioux Falls (Dr Zawada and Mr Johnson); the Departments of Medicine (Drs Mackenzie and Sica and Ms Green) and Surgery (Drs Muakkassa and Goldman), McGuire VA Medical Center and the Medical College of Virginia, Richmond.

Footnotes
Accepted for publication May 30, 1984.

Reprint requests to Division of Nephrology and Hypertension, University of South Dakota School of Medicine, 2501 W 22nd St, Sioux Falls, SD 57105 (Dr Zawada).

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