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Not a Rare Complication

Israel Heller, MD; Jonathan Halevy, MD; Shimon Cohen, MD; Emanuel Theodor, MD

Arch Intern Med. 1985;145(10):1815-1817.

Abstract
• Blood gas and serum electrolyte levels were measured in 27 elderly patients (mean age ± SD, 63.3 ± 13.5 years) who were receiving acetazolamide (250 to 1,000 mg/day) for glaucoma. Eleven glaucomatous patients (mean age, 69.1 ± 7.4 years) who were not receiving acetazolamide served as a control group. In the acetazolamide-treated group, four patients (14.8%) had mild acidosis (7.29>pH7.31), ten (37%) had moderate acidosis (7.20>pH7.29), and one patient (3.7%) had severe acidosis (pH, 7.15). None of the patients in the control group had acidosis. It is concluded that moderate metabolic acidosis of potential clinical significance is common among glaucomatous elderly patients who receive acetazolamide. The exact clinical significance of our observations is yet to be determined.

(Arch Intern Med 1985;145:1815-1817)

Author Affiliations
From the Departments of Internal Medicine "E" (Drs Halevy and Theodor) and Ophthalmology (Drs Heller and Cohen), Beilinson Medical Center, Petah Tiqva, Israel, and Tel Aviv (Israel) University Sackler School of Medicine. Dr Halevy is now at Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication Jan 2, 1985.

Reprint requests to Department of Internal Medicine "E," Beilinson Medical Center, Petah Tiqva 49100, Israel (Dr Halevy).

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