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Report of Two Cases

Christian J. Brun-Buisson, MD; Eric de Gialluly, MD; Romain Gherardi, MD; Georges Otterbein, MD; Françoise Gray, MD; Maurice Rapin, MD

Arch Intern Med. 1985;145(11):1982-1985.

Abstract
• Two cases of rapidly fatal Listeria rhombencephalitis with normal cerebrospinal fluid (CSF) findings occurred in previously healthy adults. The infection presented with nausea and headache followed by fever and signs of lower cranial nerve dysfunction, without associated meningismus, and progressed to death within four and six days of hospitalization. Because of normal CSF findings (including ventricular fluid in one patient) and negative culture results of both blood and CSF, the diagnosis was not suspected. Listeriosis should be considered early in any febrile patient presenting with signs of brain-stem dysfunction, even if CSF findings are normal.

(Arch Intern Med 1985;145:1982-1985)

Author Affiliations
From the Intensive Care Unit (Drs Brun-Buisson, de Gialluly, and Rapin), Department of Pathology (Neuropathology Unit) (Drs Gherardi and Gray), and Department of Microbiology (Dr Otterbein), Hôpital Henri Mondor and Université Paris-Val de Marne, Creteil, France.

Footnotes
Accepted for publication Jan 23, 1985.

Reprint requests to Service de Réanimation Médicale, Hôpital Henri Mondor, 94010 Creteil Cedex, France (Dr Brun-Buisson).

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