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Correlation With Liver but Not Kidney Platinum Concentrations

Amin A. Nanji, MD, FRCP(C); Nadia Z. Mikhael, MD, FRCP(C); David J. Stewart, MD, FRCP(C)

Arch Intern Med. 1985;145(11):2013-2014.

Abstract
• Hyperuricemia associated with cisplatin therapy is considered to be a consequence of cisplatin-induced nephrotoxic reactions. We correlated changes in serum uric acid levels in patients with malignant neoplasms with tissue levels of platinum and the total dose of cisplatin. In 15 patients, the serum uric acid level increased from 6.1± 1.0 mg/dL to 8.3 ±1.3 mg/dL during the time they were receiving cisplatin therapy. The change in uric acid level from baseline to peak correlated with both the total dose of cisplatin and the liver platinum concentration. There was no correlation with platinum concentration in the renal cortex and medulla.

(Arch Intern Med 1985;145:2013-2014)

Author Affiliations
From the Departments of Pathology (Drs Nanji and Mikhael) and Medicine (Dr Stewart), University of Ottawa (Ontario); Ottawa General Hospital (Drs Nanji and Mikhael); and Ontario Cancer Foundation, Ottawa (Dr Stewart).

Footnotes
Accepted for publication Jan 30, 1985.

Reprint requests to Department of Laboratory Medicine, Ottawa General Hospital, 501 Smyth Rd, Ottawa, Ontario, Canada K1H 8L6 (Dr Nanji).

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