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Masayoshi Shichiri, MD; Toshio Shinoda, MD; Yoshimaro Kijima, MD; Tatsuo Shiigai, MD; Masaaki Kanayama, MD

Arch Intern Med. 1985;145(11):2045-2047.

Abstract
• Three patients with the syndrome of inappropriate secretion of antidiuretic hormone had elevated uric acid clearances. Their uric acid clearances decreased markedly after the administration of pyrazinamide. Probenecid was given to two of them and it produced large increases in uric acid clearance. These data suggest that enhanced secretion in the renal tubules was responsible for the increased clearance of uric acid. This article provides evidence that hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone is due to increased tubular urate secretion.

(Arch Intern Med 1985;145:2045-2047)

Author Affiliations
From the Department of Internal Medicine, Yokosuka Mutual Aid Hospital, Kanagawa, Japan (Drs Shichiri, Kijima, and Kanayama) and the Second Department of Internal Medicine, Tokyo Medical and Dental University (Drs Shinoda and Shiigai). Dr Shichiri is now with the Tokyo Medical and Dental University.

Footnotes
Accepted for publication Feb 6, 1985.

Reprint requests to Yokosuka Mutual Aid Hospital, 16, Yonegahama-dori 1-chome, Yokosukashi, Kanagawa 272, Japan (Dr Kanayama).

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