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Evidence of a Geographic Variation in Frequency

Angelica C. Vitug, MD; Joel M. Goldman, MD

Arch Intern Med. 1985;145(3):473-475.

Abstract
• Recent reports suggest that 14% to 23% of thyrotoxic patients have silent (painless) thyroiditis, a newly described syndrome characterized by transient thyrotoxicosis with a low radioactive iodine uptake. A three-year review at a Brooklyn (NY) hospital showed only one definite and three possible cases of silent thyroiditis among 86 thyrotoxic patients. At most, 4% to 5% of thyrotoxic patients had silent thyroiditis. We suggest a geographic variation in this syndrome. Most cases and the largest series are from Japan and the Great Lakes area of North America. The latter may be related to increased iodine intake over many years in a previously endemic area of hypoiodidism and goiter, although other local factors may also be involved.

(Arch Intern Med 1985;145:473-475)

Author Affiliations
From the Division of Endocrinology, Department of Medicine, Coney Island Hospital (Drs Vitug and Goldman), and the Department of Medicine, Downstate Medical Center (Dr Goldman), Brooklyn, NY.

Footnotes
Accepted for publication July 19, 1984.

Reprint requests to Department of Medicine, Coney Island Hospital, 2601 Ocean Pkwy, Brooklyn, NY 11235 (Dr Goldman).

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