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Thrombocytopenia of SepsisThe Role of Circulating IgG-Containing Immune Complexes
Thomas R. Poskitt, MD;
Paula K. F. Poskitt, PhD
Arch Intern Med. 1985;145(5):891-894.
Abstract
• Platelet-associated IgG (PAIgG), circulating IgG-containing immune complexes (ICs), plasma β-thromboglobulin (β-TG), and platelet factor 4 (PF-4) levels were assayed in 33 consecutive patients with culture-proved bacteremia. Thrombocytopenia occurred in 18%, and no correlation was seen between platelet count and PAIgG, β-TG, or PF-4. In contrast, when patients were assigned to groups on the basis of rising or stable counts vs falling counts, a significant increase in the frequency of elevated PAIgG was seen in those with falling platelet counts. Elevated ICs did not correlate with PAIgG, platelet count, β-TG, or PF-4. The results of this study of patients with uncomplicated bacteremia, although clearly demonstrating intravascular platelet activation and suggesting a pathologic role for elevated PAIgG, do not support the hypothesis that platelet-bound serum ICs are responsible for either phenomenon.
(Arch Intern Med 1985;145:891-894)
Author Affiliations
From the Mt Home Veterans Administration Medical Center, and the Department of Internal Medicine, East Tennessee State University, Quillen-Dishner College of Medicine, Johnson City, Tenn.
Footnotes
Accepted for publication Sept 21, 1984.
Reprint requests to the Mt Home Veterans Administration Medical Center, Mountain Home, TN 37684 (Dr T. Poskitt).
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