'Drug Holidays' in the Treatment of Parkinson's Disease: A Brief Review

doi:10.1001/archinte.1985.00360050183031

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Vol. 145 No. 5, May 1985

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'Drug Holidays' in the Treatment of Parkinson's Disease

A Brief Review

Joseph H. Friedman, MD

Arch Intern Med. 1985;145(5):913-915.

Abstract

• "Drug holiday," the withdrawal of levodopa for a variableperiod of time, is a controversial method of treating patientswith Parkinson's disease who have levodopa-related complications.Only four studies have been published in which patients wereobserved for one year or longer. Although it is extremely beneficialfor some patients, this treatment provides a sustained one-yearbenefit for only a minority of patients.

(Arch Intern Med 1985;145:913-915)

Author Affiliations

From the Department of Medicine, Roger Williams General Hospital, and the Parkinson's Disease Referral and Information Center, Brown University, Providence, RI.

Footnotes

Accepted for publication Sept 4, 1984.

Reprint requests to Department of Medicine, Roger Williams GeneralHospital, 825 Chalkstone Ave, Providence, RI 02908 (Dr Friedman).

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