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Effect of Hemodialysis

Alan N. Elias, MD; Nosratola D. Vaziri, MD; Magdy Maksy, MD

Arch Intern Med. 1985;145(6):1013-1015.

Abstract
• The effect of hemodialysis on plasma norepinephrine (NE), epinephrine, and dopamine levels was studied in 11 patients undergoing maintenance hemodialysis. The results showed that the baseline plasma concentrations of NE and dopamine were significantly elevated in patients with end-stage renal disease undergoing maintenance hemodialysis. Intradialysis weight loss and fall in the serum glucose concentration during dialysis correlated with changes in plasma epinephrine and NE concentrations. Single-pass dialysis resulted in a marked reduction in the plasma NE concentration, indicating significant removal by dialysis. These observations should be taken into consideration when interpreting plasma catecholamine data obtained in the course of investigation of hypertensive patients with end-stage renal disease.

(Arch Intern Med 1985;145:1013-1015)

Author Affiliations
From the Divisions of Endocrinology (Dr Elias) and Nephrology (Drs Vaziri and Maksy), Department of Medicine, University of California, Irvine, Medical Center.

Footnotes
Accepted for publication Oct 18, 1984.

Reprint requests to Division of Endocrinology, University of California, Irvine, Medical Center, 101 City Dr S, Orange, CA 92668 (Dr Elias).

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