 |
|
Hypertension Management in the Multiple Risk Factor Intervention Trial (MRFIT)Six-Year Intervention Results for Men in Special Intervention and Usual Care Groups
Richard H. Grimm, Jr, MD, PhD;
Jerome D. Cohen, MD;
W. McFate Smith, MD, MPH;
Lori Falvo-Gerard, RN, MPH;
James D. Neaton, PhD
Arch Intern Med. 1985;145(7):1191-1199.
Abstract
| |
• The Multiple Risk Factor Intervention Trial was a large collaborative primary prevention trial designed to test the effects of lowering cardiovascular risk factors (ie, diastolic blood pressure [DBP], serum cholesterol, and cigarette smoking) on mortality rate from coronary heart disease in 12,866 high-risk men aged 35 to 57 years. Men were randomly assigned to either special intervention (SI) or usual care (UC) groups. Usual care men were referred to their regular source of medical care. Special intervention men were seen frequently and underwent intensive intervention intially followed by maintenance intervention in 22 different clinical centers. Hypertension intervention in SI men primarily consisted of a stepped-care pharmacologic approach designed to lower blood pressure (BP). After six years, 58.2% of SI men and 47.0% of UC men were given antihypertensive medication. In both study groups, mean systolic and diastolic BPs decreased from baseline; after six years, overall DBP was 3.2 mm Hg lower in SI men compared with UC men. In hypertensive men (DBP 90 mm Hg or those taking antihypertensive medication at baseline), after six years, DBP was 4.4 mm Hg lower in the SI group compared with the UC group. Use of specific antihypertensive agents differed substantially between the two groups. Self-reported complaints while taking antihypertensive drugs were minimal in both groups. Weight loss was associated with BP lowering in both study groups, regardless of treatment status.
(Arch Intern Med 1985;145:1191-1199)
Author Affiliations
From the Divisions of Epidemiology (Dr Grimm) and Biometry (Dr Neaton), University of Minnesota School of Public Health, Minneapolis; St Louis University School of Medicine (Dr Cohen); Medical Research Institute of San Francisco (Dr Smith); and University of Pittsburgh Graduate School of Public Health (Ms Falvo-Gerard).
Footnotes
Accepted for publication Sept 10, 1984.
A complete listing of participants involved in conducting the Multiple Risk Factor Intervention Trial immediately follows this article.
Reprint requests to the Division of Epidemiology, School of Public Health, University of Minnesota, 611 Beacon St SE, Minneapolis, MN 55455 (Dr Grimm).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
A Risk Score for Predicting Near-Term Incidence of Hypertension: The Framingham Heart Study
Parikh et al.
ANN INTERN MED 2008;148:102-110.
ABSTRACT
| FULL TEXT
Glucose-Cholesterol Interaction Magnifies Coronary Heart Disease Risk for Hypertensive Patients
Cohen et al.
Hypertension 2004;43:983-987.
ABSTRACT
| FULL TEXT
The inflammatory process in intermittent claudication
Belch et al.
Eur Heart J Suppl 2002;4:B31-B34.
ABSTRACT
Long-term Effects on Sexual Function of Five Antihypertensive Drugs and Nutritional Hygienic Treatment in Hypertensive Men and Women: Treatment of Mild Hypertension Study (TOMHS)
Grimm et al.
Hypertension 1997;29:8-14.
ABSTRACT
| FULL TEXT
Renal Function Change in Hypertensive Members of the Multiple Risk Factor Intervention Trial: Racial and Treatment Effects
Walker et al.
JAMA 1992;268:3085-3091.
ABSTRACT
Chromium and High-Density Lipoprotein Levels in Men Taking Beta-Blockers
Fletcher
ANN INTERN MED 1992;117:91-93.
ABSTRACT
The white blood cell as a risk factor for thrombotic vascular disease
Belch
Vasc Med 1990;1:203-213.
Nutritional Therapy for High Blood Pressure: Final Report of a Four-Year Randomized Controlled Trial-- The Hypertension Control Program
Stamler et al.
JAMA 1987;257:1484-1491.
ABSTRACT
|
