 |
|
Long-term Efficacy of Deferoxamine Iron Chelation Therapy in Adults With Acquired Transfusional Iron Overload
Andrew I. Schafer, MD;
Steven Rabinowe, MD;
Meryl S. Le Boff, MD;
Kenneth Bridges, MD;
Robert G. Cheron, MD;
Robert Dluhy, MD
Arch Intern Med. 1985;145(7):1217-1221.
Abstract
• Transfusional iron overload in adult patients with acquired anemias may result in widespread organ dysfunction. Long-term deferoxamine mesylate therapy was administered by continuous subcutaneous infusion to six such patients, who have been followed up for up to 66 months of therapy while continuing to be transfusion-dependent. During deferoxamine therapy, liver density by computed tomographic scan decreased in four of five patients, liver iron content decreased in two of three patients, and liver function normalized in two patients. Plasma cortisol response to insulin-induced hypoglycemia improved in three of five patients receiving therapy. Pituitary growth hormone reserve normalized in two patients and remained normal in the other three tested. One patient, treated concurrently with ascorbic acid, died suddenly. The other five patients have had no cardiac deterioration by noninvasive testing. We conclude that long-term deferoxamine iron chelation therapy is effective not only in retarding but, in some cases, even reversing organ damage caused by transfusional iron overload.
(Arch Intern Med 1985;145:1217-1221)
Author Affiliations
From the Hematology (Drs Schafer and Bridges) and Endocrinology (Drs Rabinowe, Le Boff, Cheron, and Dluhy) Divisions, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston.
Footnotes
Accepted for publication Oct 30, 1984.
Read in part before the 25th annual meeting of the American Society of Hematology, San Francisco, Dec 5, 1984.
Reprint requests to Hematology Division, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (Dr Schafer).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Clinical Relevance of Anemia and Transfusion Iron Overload in Myelodysplastic Syndromes
Cazzola et al.
ASH Education Book 2008;2008:166-175.
ABSTRACT
| FULL TEXT
Iron-Chelating Therapy and the Treatment of Thalassemia
Olivieri and Brittenham
Blood 1997;89:739-761.
FULL TEXT
Hemochromatosis: Treatment to Alleviate Injury
Crosby
Arch Intern Med 1986;146:1910-1911.
ABSTRACT
|
