The Aging Thyroid: Thyroid Deficiency in the Framingham Study

doi:10.1001/archinte.1985.00360080056006

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Vol. 145 No. 8, August 1985

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The Aging Thyroid

Thyroid Deficiency in the Framingham Study

Clark T. Sawin, MD; William P. Castelli, MD; Jerome M. Hershman, MD; Patricia McNamara; Pamela Bacharach

Arch Intern Med. 1985;145(8):1386-1388.

Abstract

• In an unselected population of elderly (over age 60 years)men and women (the original cohort of the Framingham Study),the prevalence of thyroid deficiency, evidenced by a clearlyelevated serum thyrotropin (TSH) level (>10 µU/mL),was 4.4%. Women had thyroid deficiency (5.9%) more often thanmen (2.3%). Of those with clearly elevated serum TSH levels,only 39% had low serum thyroxine (T₄) levels; the remainderhad serum T₄ levels in the lower half of the normal range. Others(5.9%) had a slightly elevated serum TSH level (5 to 10 µU/mL);their status was not clear, but more (12.7%) had low T₄ levelsthan expected. The level of serum T₄ was not a sensitive measureof thyroid deficiency nor was routine examination by a physician,even when the patient's background contained a clue to a possiblethyroid problem. An elevated serum TSH level was a sensitivemarker of thyroid deficiency in the elderly and was often theonly way to detect it. Further studies are needed to determinethe relationship of thyroid deficiency to cognitive and cardiovascularfunction in older persons.

(Arch Intern Med 1985;145:1386-1388)

Author Affiliations

From the Medical Service, Boston Veterans Administration Medical Center (Dr Sawin and Ms Bacharach); the Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Mass (Dr Castelli and Ms McNamara); the Medical Service, Wadsworth Veterans Administration Medical Center, Framingham, Mass (Dr Hershman); and the Departments of Medicine, Tufts University School of Medicine, Boston (Dr Sawin); and UCLA School of Medicine, Los Angeles (Dr Hershman).

Footnotes

Accepted for publication Nov 26, 1984.

Reprint requests to Veterans Administration Medical Center,150 S Huntington Ave, Boston, MA 02130 (Dr Sawin).

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