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Multiple Myeloma in Three Siblings
Leonard J. Horwitz, MD;
Robert N. Levy, MD;
Fred Rosner, MD
Arch Intern Med. 1985;145(8):1449-1450.
Abstract
• All three siblings of a family developed multiple myeloma. Two siblings had a history of monoclonal gammopathy; in one of these two siblings and in the third sibling, the disease progressed rapidly. A review of the literature shows that of 38 previously reported pairs of siblings with plasma cell disorders, eight families had a third affected sibling and four another affected relative. This clinical clustering suggests that some cases of multiple myeloma may have a hereditary basis and that other family members may be at risk for developing the disease.
(Arch Intern Med 1985;145:1449-1450)
Author Affiliations
From the Department of Medicine (Division of Hematology/Oncology), Long Island Jewish Medical Center, New Hyde Park, NY. Dr Horwitz is now with the Department of Hematology, University of Texas M. D. Anderson Hospital, Houston.
Footnotes
Accepted for publication Nov 12, 1984.
Reprint requests to Box 55, University of Texas M. D. Anderson Hospital, 6723 Bertner Ave, Houston, TX 77030 (Dr Horwitz).
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