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Follow-up With Serial Thyroid Biopsies

Nobuto Wakakuri, MD; Tadashi Kubo, MD; Masanobu Kitagawa, MD

Arch Intern Med. 1985;145(8):1527-1528.

Abstract
• Hyperthyroidism occurred following primary hypothyroidism in a 46-year-old man with serologically and histologically proved chronic lymphocytic thyroiditis. Repeated thyroid biopsy specimens revealed that histologic features compatible with chronic lymphocytic thyroiditis seen at the initial hypothyroid state subsequently underwent a remarkable resolution, with titers of circulating antithyroid antibodies being reduced in correspondence with the histologic improvement. This case shows that primary hypothyroidism in adults can spontaneously evolve into a hyperthyroid state, as has been suggested previously, and that the histologic abnormalities in chronic lymphocytic thyroiditis may not necessarily be irreversible.

(Arch Intern Med 1985;145:1527-1528)

Author Affiliations
From the Department of Internal Medicine, Toyama (Japan) Prefectural Central Hospital (Drs Wakakuri and Kubo), and the Department of Pathology, Faculty of Medicine, Toyama (Japan) Medical and Pharmaceutical University (Dr Kitagawa).

Footnotes
Accepted for publication Jan 23, 1985.

Reprint requests to Department of Internal Medicine, Toyama Prefectural Central Hospital, Nishinagae 220, Toyama City, Japan 930 (Dr Kubo).

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