This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

William B. White, MD

Arch Intern Med. 1985;145(9):1717-1718.

Abstract
• A 74-year-old woman with a history of cerebrovascular disease developed profound central nervous system (CNS) and respiratory depression, generalized hypotonia, sinus bradycardia, and urinary retention following an increase in dose of baclofen, an antispasticity agent. Before receiving baclofen therapy the patient had had minor urinary dysfunction associated with a remote cerebrovascular accident but no urinary retention. Cessation of baclofen therapy and the relief of the urinary obstruction improved mental status and normalized motor function within 24 hours. A withdrawal syndrome of agitation, hallucinosis, and convulsive activity persisted for eight days following discontinuation of the baclofen. Our experience suggests that patients with various forms of CNS disease states may be at risk of serious CNS depression with even small therapeutic doses of baclofen.

(Arch Intern Med 1985;145:1717-1718)

Author Affiliations
From the Department of Medicine, University of Connecticut School of Medicine, Farmington.

Footnotes
Accepted for publication Feb 27, 1985.

Reprint requests to L-2071A, University of Connecticut Health Center, Farmington, CT 06032 (Dr White).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Baclofen unerotoxicity in a chronic haemodialysis patient
Bassilios et al.
Nephrol Dial Transplant 2000;15:715-716.
FULL TEXT  

Periodic Sharp Waves in Baclofen-Induced Encephalopathy
Hormes et al.
Arch Neurol 1988;45:814-815.
ABSTRACT