 |
|
Thromboangiitis Obliterans Associated With Idiopathic Hypereosinophilia
Gary T. Ferguson, MD;
Gordon Starkebaum, MD
Arch Intern Med. 1985;145(9):1726-1728.
Abstract
• A 47-year-old male smoker with chronic eosinophilia developed progressive ischemia in his extremities. Pathologic examination of vessels in amputated limbs revealed changes of thromboangiitis obliterans. Focal segments of some arteries, however, revealed infiltration of thrombus and vessel wall by eosinophils. Furthermore, the patient developed a totally occluded right temporal artery, which on biopsy specimen showed marked infiltration by eosinophils within the vessel wall. In contrast to most patients with the hypereosinophilic syndrome, however, this patient had no evidence of endomyocardial thrombosis or fibrosis. In view of recent evidence that eosinophil granule proteins are toxic to endothelial cells, the findings in this patient suggest the possibility that eosinophils may be involved in the pathogenesis of thromboangiitis obliterans.
(Arch Intern Med 1985;145:1726-1728)
Author Affiliations
From the Medical Service, Veterans Administration Medical Center (Drs Ferguson and Starkebaum), and the Department of Medicine, Division of Rheumatology, University of Washington (Dr Starkebaum), Seattle.
Footnotes
Accepted for publication March 5, 1985.
Reprints not available.
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Superficial Venous Thrombophlebitis as the Initial Manifestation of Hypereosinophilic Syndrome: Study of the First 3 Cases
Terrier et al.
Arch Dermatol 2006;142:1606-1610.
ABSTRACT
| FULL TEXT
|
