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Influenza Vaccine and Pneumonia Mortality in a Nursing Home Population
Alfred J. Saah, MD, MPH;
Richard Neufeld, MD;
Manuel Rodstein, MD;
John R. La Montagne, PhD;
William C. Blackwelder, PhD;
Peter Gross, MD;
Gerald Quinnan, MD;
Richard A. Kaslow, MD, MPH
Arch Intern Med. 1986;146(12):2353-2357.
Abstract
• The effectiveness of immunization against influenza in elderly persons is uncertain. A retrospective cohort study in a New York City nursing home examined the occurrence of pneumonia and its related mortality over three consecutive influenza seasons (Nov 1 through April 30,1979 to 1980,1980 to 1981, and 1981 to 1982). Nearly one half of approximately 450 residents (mean age, 84 years) accepted immunization each year. The vaccinated and unvaccinated groups were similar. The attack rate of pneumonia did not differ significantly between the vaccinated and unvaccinated groups in any of the three influenza seasons. When influenza was occurring in the community (1979 to 1980 and 1980 to 1981), however, the risk of death from pneumonia in the unvaccinated group was threefold higher than in the vaccinated group (60% vs 18% and 73% vs 25%, respectively). In a year when influenza was specifically sought and not found in the facility (1981
Author Affiliations
From the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (Drs Saah, La Montagne, Blackwelder, and Kaslow); the Jewish Home and Hospital for Aged, New York (Drs Neufeld and Rodstein); the Hackensack (NJ) Medical Center (Dr Gross); and Office of Biologics, the Food and Drug Administration, Bethesda, Md (Dr Quinnan).
Footnotes
Accepted for publication Jan 20, 1986.
Read in part before the meeting of the American Public Health Association, Montreal, Nov 15, 1982.
Reprint requests to National Institute of Allergy and Infectious Diseases, National Institutes of Health, Westwood Building, Room 739, Bethesda, MD 20892 (Dr Saah).
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