You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


Advertisement

ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | RSS | Access Rights | Sign In


  Vol. 146 No. 12, December 1986 TABLE OF CONTENTS
  Online Only
 •  Online First Table of
Contents
  ORIGINAL INVESTIGATIONS
 •Online Features
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (74)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Delicious Add to Digg Add to Facebook Add to Reddit Add to Technorati Add to Twitter What's this?

Nonsteroidal Anti-inflammatory Drugs and Gastrointestinal Bleeding

A Case-Control Study

William R. Bartle, PharmD; Aditya K. Gupta, MA; Jana Lazor, MScPharm

Arch Intern Med. 1986;146(12):2365-2367.


Abstract



• This study looked at the association between nonsteroidal anti-inflammatory drug (NSAID) use and acute nonvariceal upper gastrointestinal tract bleeding (AUGIB). Fifty-seven consecutive patients presenting to hospital with AUGIB were compared with 123 sex- and age-matched controls. Twenty-four (42.1%) of the 57 AUGIB patients were taking NSAIDs compared with 23 (18.1%) of the 123 control subjects. Patients whose AUGIB was associated with NSAID use were significantly older than the group whose bleeding was not associated with drug use; no other differences between these two groups was found. Seventy percent of patients taking nonacetylsalicylic acid who developed bleeding in this study did so within three months of starting therapy. Abdominal pain was an infrequent presenting complaint.

(Arch Intern Med 1986;146:2365-2367)



Author Affiliations



From the Department of Pharmacy (Dr Bartle and Ms Lazor) and Medicine (Dr Gupta), Sunnybrook Medical Centre, Faculty of Pharmacy, University of Toronto.


Footnotes



Accepted for publication March 26, 1986.

Reprint requests to Department of Pharmacy, Sunnybrook Medical Centre, University of Toronto, 2075 Bayview Ave, Toronto, Ontario, Canada M4N 3M5 (Dr Bartle).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Delicious Delicious   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The influence of cyclo-oxygenase specificity of non-steroidal anti-inflammatory drugs on bleeding complications in concomitant coumarine users
Knijff-Dutmer et al.
QJM 2003;96:513-520.
ABSTRACT | FULL TEXT  

Concomitant Coumarin-NSAID Therapy and Risk for Bleeding
Knijff-Dutmer et al.
The Annals of Pharmacotherapy 2003;37:12-16.
ABSTRACT | FULL TEXT  

Adverse Gastrointestinal Effects of Nonsteroidal Anti-Inflammatory Drugs
Erstad and Lipsy
Journal of Pharmacy Practice 1994;7:144-153.
ABSTRACT  

Striking Prevalence of Over-the-Counter Nonsteroidal Anti-inflammatory Drug Use in Patients With Upper Gastrointestinal Hemorrhage
Wilcox et al.
Arch Intern Med 1994;154:42-46.
ABSTRACT  

A Meta-analysis of the Effects of Nonsteroidal Anti-inflammatory Drugs on Blood Pressure
Pope et al.
Arch Intern Med 1993;153:477-484.
ABSTRACT  

Cost-Conscious Prescribing of Nonsteroidal Anti-inflammatory Drugs for Adults With Arthritis: A Review and Suggestions
Greene and Winickoff
Arch Intern Med 1992;152:1995-2002.
ABSTRACT  

The Impact of Research Quality and Study Design on Epidemiologic Estimates of the Effect of Nonsteroidal Anti-inflammatory Drugs on Upper Gastrointestinal Tract Disease
Bollini et al.
Arch Intern Med 1992;152:1289-1295.
ABSTRACT  

Massive Gastrointestinal Bleeding Associated With Ketorolac Administration
Erstad and Neumayer
Journal of Pharmacy Practice 1992;5:xi-xii.
 

Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs: A Meta-analysis
Gabriel et al.
ANN INTERN MED 1991;115:787-796.
ABSTRACT  

Cost-effectiveness of Misoprostol for Prophylaxis Against Nonsteroidal Anti-inflammatory Drug--Induced Gastrointestinal Tract Bleeding
Edelson et al.
JAMA 1990;264:41-47.
ABSTRACT  

Nonsteroidal Anti-Inflammatory Drug Use and Death from Peptic Ulcer in Elderly Persons
Griffin et al.
ANN INTERN MED 1988;109:359-363.
ABSTRACT  

Nonsteroidal Anti-Inflammatory Drugs Activate Quiescent Inflammatory Bowel Disease
KAUFMANN and TAUBIN
ANN INTERN MED 1987;107:513-516.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | PHYSICIAN JOBS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1986 American Medical Association. All Rights Reserved.