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Plasmapheresis, Plasma Transfusion, and Vincristine

Marion L. Sennett, MD; Marcel E. Conrad, MD

Arch Intern Med. 1986;146(2):266-267.

Abstract
• In four patients with thrombotic thrombocytopenic purpura (TTP), the administration of plasma exchange and vincristine sulfate was associated with reversal of clinical and hematologic evidence of disease. Plasmapheresis with fresh frozen plasma replacement appears effective in acutely improving neurologic and hematologic abnormalities of patients with TTP and provides time for vincristine to become effective and induce lasting remissions. One patient with early relapse responded to a second short course of vincristine without other therapy. These data suggest that these treatment modalities should be considered as the initial treatment of TTP.

(Arch Intern Med 1986;146:266-267)

Author Affiliations
From the Department of Medicine, University of South Alabama, Mobile.

Footnotes
Accepted for publication May 3, 1985.

Reprint requests to University of South Alabama Medical Center, Mobile, AL 36617 (Dr Sennett).

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