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Madhusudan Budhraja, MD; Isabel Danel, MD

Arch Intern Med. 1986;146(2):311-315.

Abstract
• Tight metabolic control of manifest diabetes during pregnancy was attempted in 51 clinic referrals to a county hospital. Starting before the 28th week of gestation, a good control of diabetes was achieved with the help of initial hospitalization, regular home blood glucose monitoring, and frequent clinic visits. Mean preprandial plasma glucose level was 96.4± 22.6 mg/dL. A mean preprandial plasma glucose level of less than 110 mg/dL was achieved in 42 (82%) of the 51 patients. Total perinatal mortality was 7.7% (4/52). When we excluded major maternal morbidity unrelated to diabetes that accounted for fetal loss, the corrected perinatal loss was 3.8%. Significant maternal hypoglycemia was uncommon. Major congenital malformations in the fetus, neonatal hyperbilirubinemia, and neonatal hypoglycemia each occurred in fewer than 5%. These results suggest that good metabolic control of diabetes is achievable in patients in a general hospital and it may lower fetal loss and morbidity associated with overt maternal diabetes.

(Arch Intern Med 1986;146:311-315)

Author Affiliations
From the Division of Endocrinology, Department of Medicine, Cook County Hospital, Chicago.

Footnotes
Accepted for publication May 15, 1985.

Reprint requests to Division of Endocrinology, Room 201, Main Bldg, Cook County Hospital, 1825 W Harrison St, Chicago, IL 60612.

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