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A Prospective Study

Hsiao-Min Chung, MD; Rudiger Kluge, MD; Robert W. Schrier, MD; Robert J. Anderson, MD

Arch Intern Med. 1986;146(2):333-336.

Abstract
• In the present study, we found that at least 4.4% of 1,088 prospectively studied patients developed postoperative hyponatremia (plasma sodium concentration <130 mEq/L). Most patients (42%) were normovolemic. Edematous states (21%), hyperglycemia (21%), volume depletion (8%), and renal failure (8%), however, were also common settings of postoperative hyponatremia. Plasma arginine vasopressin was present in all patients in whom it was measured and 94% of the patients were receiving hypotonic fluid at the time of development of hyponatremia. Hyponatremia was not associated with significant neurologic deterioration in the 48 postoperative patients in the present study. In eight patients, however, the positive water balance that resulted in hyponatremia was associated with development of pulmonary vascular congestion. We conclude that hyponatremia commonly occurs following all types of surgical procedures and is due to hypotonic fluid administration in the presence of nonosmotic secretion of arginine vasopressin.

(Arch Intern Med 1986;146:333-336)

Author Affiliations
From the Division of Renal Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver. Dr Chung is now with the Veterans General Hospital, Taipei, Taiwan. Dr Kluge is now in private practice in Heilbronn, West Germany.

Footnotes
Accepted for publication May 29, 1985.

Reprint requests to Division of Renal Diseases, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Box C280, Denver, CO 80262 (Dr Anderson).

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